Benzaldehyde, 3,4-bis(difluoroMethoxy)-

Benzaldehyde, 3,4-bis(difluoroMethoxy)- - Names and Identifiers

Name	3,4-BIS-DIFLUOROMETHOXY-BENZALDEHYDE
Synonyms	Roflumilast Impurity K 3,4-BIS-DIFLUOROMETHOXY-BENZALDEHYDE Benzaldehyde, 3,4-bis(difluoroMethoxy)-
CAS	127842-54-0
EINECS	1312995-182-4

Benzaldehyde, 3,4-bis(difluoroMethoxy)- - Physico-chemical Properties

Molecular Formula	C9H6F4O3
Molar Mass	238.14
Density	1.387±0.06 g/cm3 (20 ºC 760 Torr)
Boling Point	265.8±35.0℃ (760 Torr)
Flash Point	111.1±20.8℃
Water Solubility	Chloroform (Slightly), Methanol (Slightly)
Appearance	Shape Oil Color Clear Light Yellow
Storage Condition	under inert gas (nitrogen or Argon) at 2-8°C
MDL	MFCD08706075

Benzaldehyde, 3,4-bis(difluoroMethoxy)- - Upstream Downstream Industry

Raw Materials

4-Difluoromethoxy-3-hydroxybenzaldehyde
Difluorochloromethane
Protocatechualdehyde

Benzaldehyde, 3,4-bis(difluoroMethoxy)- - Introduction

3, is an organic compound whose molecular formula is C9H6F2O2.

Nature:
-Appearance: Colorless to light yellow liquid
-Melting point:-15 ° C
-Boiling Point: 75-80 ° C(0.15 mmHg)
-Density: 1.326g/cm³(20 ° C)
-Stability: stable, does not react with air and water at room temperature

Use:
3, has certain application in the field of medicine and pesticide:
-In the field of medicine, it can be used as an intermediate for the synthesis of biologically active molecules, such as antibacterial drugs and anti-cancer drugs;
-In the field of pesticides, it can be used to synthesize pesticides with insecticidal activity.

Method:
3, It can be synthesized by the following steps:
1. First, benzaldehyde is reacted with boron trifluoride to generate trifluoroborate ester;
2. Then, the trifluoroborate Ester is etherified with difluoromethanol to generate 3,4-bis (difluoromethoxy) anisole;
3. Finally, 3,4-bis (difluoromethoxy) anisole is treated with sodium hydroxide and subjected to demethylation reaction to obtain 3.

Safety Information:
Safety data on 3 is limited. As a chemical, it should comply with the safe handling of chemicals, such as wearing appropriate protective equipment (such as gloves, glasses, protective clothing, etc.), avoid inhalation, contact with skin and eyes. Avoid contact with strong oxidants and high temperature substances. In case of inhalation or skin contact, seek medical attention.

Last Update：2024-04-09 21:54:55